Each region of the genome replicates at a characteristic time, determined by the time that the replication origins activate. We have developed genomic approaches to measure origin activation and the times at which regions of the genome replicate. However, within individual cells replication origins activate stocastically, therefore each cell use a different combination of origins to replication the genome. The video clip (below) shows an example of one possible scenario for the replication of chromosome VI. We are interested in understanding what regulates the activity of origins and how the cell ensures that sufficient, appropriately distributed, origins are activated to complete genome replication in the time available.

 
Each region of the genome replicates at a characteristic time, determined by the time that the replication origins activate. We have developed genomic approaches to measure origin activation and the times at which regions of the genome replicate. However, within individual cells replication origins activate stocastically, therefore each cell use a different combination of origins to replication the genome. The video clip (above) shows an example of one possible scenario for the replication of chromosome VI. We are interested in understanding what regulates the activity of origins and how the cell ensures that sufficient, appropriately distributed, origins are activated to complete genome replication in the time available.